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Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics.

Ethics and addiction --- Drugs --- Drug development. --- Piperidine. --- Design.

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The purpose of Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven drug discovery to the biomedical community at large. The book emphasizes the use of 'new variables' and more objective numerical methods to drive drug discovery in an encompassing way. These 'new variables' are based on Ligand Efficiency Indices (LEIs) formulated in a way that permits mapping Chemico-Biological Space (CBS) in an Atlas-like representation. It provide

Ethics and addiction --- Drug development. --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Development

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The Future of Drug Discovery: Who decides which diseases to treat? provides a timely and detailed look at the efforts of the pharmaceutical industry and how they relate, or should relate, to societal needs. The authors posit that as a result of increasing risk aversion and accelerated savings in research and development, the industry is not developing drugs for increasingly prevalent diseases, such as Alzheimer's disease, untreatable pain, antibiotics and more. This book carefully exposes the gap between the medicines and therapies we need and the current business path. By ana

Ethics and addiction --- Economics --- Pharmaceutical industry. --- Drug industry --- Drug trade --- Medicine industry --- Medicines industry --- Prescription medicine industry --- Chemical industry --- Drug development. --- Drugs --- Design.

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Ethics and addiction --- Zoology --- Toxicology --- Veterinary pharmacology --- Veterinary medicine --- Veterinary toxicology. --- Toxicology. --- Poisoning --- Drug toxcity --- Toxicity Tests. --- Toxicologie vétérinaire. --- Intoxication --- Tests de toxicité. --- veterinary. --- veterinary --- Chez les animaux. --- Drug toxicity --- Toxicity Tests --- Drug-Related Side Effects and Adverse Reactions

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Ethics and addiction --- Drug development. --- Polymeric drug delivery systems. --- Drug delivery systems --- Polymers in medicine --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Development --- Drug Delivery Systems. --- Polymers.